Using sugar to detect malignant tumours

Using sugar to detect malignant tumours



Ordinary sugar could become a contrast agent of the future for use in magnetic resonance tomography examinations of tumours. Malignant tumours show higher sugar consumption than surrounding tissue.

“If sugar replaces metal as a contrast agent in the body, it can also have a positive psychological effect and make patients calmer,” says Linda Knutsson, senior lecturer at Lund University in Sweden.

A tumour’s properties can be examined by injecting a small amount of sugar into it, and then measuring how much sugar the tumour consumes. The more sugar the tumour consumes, the more malignant it is.

Linda Knutsson is working with a team from Johns Hopkins University in the USA, which has developed a new imaging technique for magnetic resonance tomography. The collaboration has resulted in the new imaging technique being combined with the testing of natural sugar as a replacement for metal in contrast agents.

There is no similar clinical research in this area. It is the first time a non-synthetic contrast agent has been used in human magnetic resonance tomography examinations, and the results are promising. The uptake of sugar is higher in the tumour than in healthy tissue according to the results of tests carried out by Lund University and the Johns Hopkins team in the USA. The tests were carried out on three persons with a brain tumour and four healthy persons and published in the research journal Tomography in December last year. A more detailed study on a large group of patients is to commence soon in Lund.

“Metal-based contrast agents cost more than sugar-based agents. Accordingly, this could lead to a reduction in medical care costs,” says Linda Knutsson.

A disadvantage is that sugar-based contrast agents cannot be used in examinations of diabetes patients.

More information: Dynamic Glucose-Enhanced (DGE) MRI: Translation to Human Scanning and First Results in Glioma Patients. Tomography, December 2015, Volume 1, Issue 2: 105-114 DOI: 10.18383/j.tom.2015.00175

[Medical Xpress]
February 22, 2016 / by / in , , , , , , , ,

Leave a Reply

Show Buttons
Hide Buttons

IMPORTANT MESSAGE: is a website owned and operated by Scooblr, Inc. By accessing this website and any pages thereof, you agree to be bound by the Terms of Use and Privacy Policy, as amended from time to time. Scooblr, Inc. does not verify or assure that information provided by any company offering services is accurate or complete or that the valuation is appropriate. Neither Scooblr nor any of its directors, officers, employees, representatives, affiliates or agents shall have any liability whatsoever arising, for any error or incompleteness of fact or opinion in, or lack of care in the preparation or publication, of the materials posted on this website. Scooblr does not give advice, provide analysis or recommendations regarding any offering, service posted on the website. The information on this website does not constitute an offer of, or the solicitation of an offer to buy or subscribe for, any services to any person in any jurisdiction to whom or in which such offer or solicitation is unlawful.