Exploding nanobubbles can kill cancer cells

Exploding nanobubbles can kill cancer cells
 sn-nanocancer

Clusters of gold nanoparticles sit on the surface of a cancer cell. When hit with a burst of infrared light, the clusters vaporize nearby water, creating bubbles of vapor that burst and tear apart the cell.

D. S. Wagner et al., Biomaterials, 31 (2010)

Clusters of gold atoms can detect and kill cancer cells commonly left behind after tumor-removal surgery, according to a study of a new nanotechnology technique. For now, the approach has only been tried in a handful of mice. But the researchers are designing a clinical trial that could begin testing the therapy in humans in the next 2 years. If the technique proves successful in people, it could dramatically improve the odds for cancer patients, particularly in cases where surgically removing an entire tumor is impossible.

When surgeons operate on cancer patients, they do their best to remove every last diseased cell, because any left behind can grow into new tumors or metastasize throughout the body. Oncologists then typically follow up surgery with either radiation treatments or chemotherapy to increase the chances of eliminating any residual tumor cells. But this standard approach to fighting cancer is anything but foolproof.

In recent years, physicians and scientists have looked to nanotechnology for help. One approach pioneered over the last decade by researchers at Rice University in Houston, Texas, and elsewhere has shown that clusters of gold atoms known as nanoparticles can serve as a potent weapon against cancer cells. Solid cancer tumors typically have leaky blood vessels. As a result, when gold nanoparticles are injected into the bloodstream, they tend to seep out of the vessel openings and congregate around tumors. To clean up their surroundings, those cells then often engulf the nanoparticles. But once inside the cells, the nanoparticles can act as Trojan horses. When researchers hit the gold atoms with infrared laser light, which can travel through centimeters of tissue, the particles heat up and kill the cancer cells.

Unfortunately, the nanoparticle heater strategy has two problems, says Dmitri Lapotko, a physicist formerly with Rice and now head of laser science at Masimo Corporation, a medical nanotechnology company in Irvine, California. The first is that some gold nanoparticles invariably end up in and around normal cells, so healthy tissue can get damaged when the lasers go after cancers. As well, the lasers that are normally used for heating the particles fire continuous beams of infrared light. This too spreads the heat far beyond cancer cells and into the normal tissue. In cases where tumors grow in and around vital tissues, such as nerves or arterial walls, any collateral damage to healthy tissues can be debilitating or dangerous.

In an effort to narrow the therapy’s focus, Lapotko and colleagues sought to modify the approach to zapping nanoparticles. They started with mice that had been implanted with human squamous cell carcinoma, cancer cells common in human head and neck tumors that are particularly difficult to treat with standard therapies. They decorated their gold nanoparticles with immune protein antibodies, which specifically latch onto receptors that sit on the surface of squamous cells. That concentrated the particles, creating clusters of dozens of them in and around cancer cells. And instead of firing continuous laser beams, the researchers fired only ultrashort infrared pulses.

As hoped, this prevented the heat from spreading to surrounding normal tissues. But the approach had an even more important effect: It caused temperatures to rise higher where there were large clusters of gold nanoparticles. This vaporized adjacent water molecules, creating tiny bubbles that quickly expand and burst, ripping apart the cancer cells. They key, Lapotko says, is that “nanoparticle clusters produce nanobubbles in cancer cells and not normal tissue.”

Online today inNature Nanotechnology, Lapotko and his colleagues report that those mini-explosions made it possible not only to pick up sound from where tumor cells were located—and thereby detect the presence of as few as three cancer cells—but it also destroyed the cells in the process. For cases in which it was possible to surgically resect most of the cancer tissue, 100% of the animals survived, thanks to the fact that no residual cancer cells remained alive. And in cases where only partial surgical removal of a tumor was an option, the survival rate for the animals doubled.

“This is very, very interesting,” says Mien-Chie Hung of the University of Texas MD Anderson Cancer Center in Houston, who is exploring treating tumors with nanoparticles. Hung notes that the approach dovetails very well with conventional surgery that is able to remove large tumors but is unable to identify cancer cells that remain behind. The new technique, he says, acts like microscopic surgery to target those residual cells. Hung emphasizes that many oncology approaches that work in animals never wind up as effective in humans. But if this one does, it could open a whole new window into spotting and eliminating residual cancer cells left behind after surgery.

DOI: 10.1126/science.aaf4067

[Science]

February 22, 2016 / by / in , , , , ,

Leave a Reply

Show Buttons
Hide Buttons

IMPORTANT MESSAGE: Scooblrinc.com is a website owned and operated by Scooblr, Inc. By accessing this website and any pages thereof, you agree to be bound by the Terms of Use and Privacy Policy, as amended from time to time. Scooblr, Inc. does not verify or assure that information provided by any company offering services is accurate or complete or that the valuation is appropriate. Neither Scooblr nor any of its directors, officers, employees, representatives, affiliates or agents shall have any liability whatsoever arising, for any error or incompleteness of fact or opinion in, or lack of care in the preparation or publication, of the materials posted on this website. Scooblr does not give advice, provide analysis or recommendations regarding any offering, service posted on the website. The information on this website does not constitute an offer of, or the solicitation of an offer to buy or subscribe for, any services to any person in any jurisdiction to whom or in which such offer or solicitation is unlawful.